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Wednesday, November 30, 2016

Diet Roadblock Explained

As we help women achieve and maintain a healthy BMI, we see too many people in the middle of a successful diet, suddenly struggling to maintain the pace of weight loss. Knowing the cause can help guide us to a solution. Hormones pay a role in the regulation of weight and food consumption. These are hormones that most of us do not discuss with our providers. But understanding these hormones will help explain why so many of us hit a roadblock when tying to lose weight. When you begin a diet you find that you lose weight, but as you go on watching your calories you find that weight loss slows, and in some cases that weight gain resumes. When we eat food, normally when we are not trying to gain or lose weight as we at the leptin hormone from our fat decreases, the ghrelin from the stomach increases, the hormones glucagon-like peptide-1, cholecystokinin, and peptide YY from our intestine, and insulin and amylin from the pancreases all decrease. Those effects help regulate the signal to regulate the food intake and regulate aspects of our metabolism. If we look at those same levels after weight loss as early as 10 weeks into a diet some of these same hormone levels change so their effects are paradoxically changed to produce more hunger and makes you less feeling full after eating. If you were able to keep these hormones elevated you would have more satisfaction from your food, feeling fuller after you eat, less feelings of hunger between meals, and as a result be able to eat less and maintain balanced weight loss. Medications, exercise, CoolSculpting and Slim Shots can all help you be successful. Helping you fight the roadblocks these gut and fat hormones present mid diet as you struggle with weight issues and factors that are beyond your control is how the medication Saxenda works. Perhaps this is one option for you to explore with your gyno.

Friday, November 25, 2016

New Cervical Cancer Tests and How They Relate To Anti-Aging Medicine

In a new study on urine Johns Hopkins Medicine scientists have detected a way on a urine test to test for cervical cancer risk.  Prevention and early detection has long been the world wide strategy to prevent cervical cancer. The world wide vaccine program is aimed at almost complete elimination of cervical cancer. In those not vaccinated we have developed n genetic markers derived directly from cervical tissue that can help detect those that should be tested for the precancerous changes of the cells that precedes actual invasive disease. The test on urine, which most patients would tell you is much easier and better tolerated than actual cervical swaps combines looking for HPV DNA and .
s of human cellular DNA altered by precancerous changes. This early study online in Cancer Prevention Research on November 8, the investigators say their genetic markers test showed a  accuracy rate of 90.9 percent in identifying so-called CIN2 lesions which are the high grade cervical changes that have at least 1/10 chance of becoming a malignancy if untreated. Additionally, they demonstrated that the DNA for all three human genes and one viral gene could be successfully extracted from urine, and they could identify such lesions with 75 percent sensitivity. Antiaging medicine has shown that oxidation, methylation, glycosilation, and chelation of our cells, our DNA, and our tissues ages us. Aging processes can also lead to cancer.  Two tests based on markers of DNA chemical changes called methylation, released in Europe last summer, and are an advancement in the science of cervical cancer detection but do require Pap smear swabs of cervical tissue, and show 64 percent sensitivity in identifying similar lesions,  and of course then require further testing, which can be both uncomfortable and expensive to really detect any new disease. The emphasis in cervical cancer detection strategies has been how to prevent disease with more targeted testing, and fewer tests.This new test could help establish who to watch and not do further testing on. Their new test looks at  three genes associated with cervical cancer or abnormal-looking cells known to become cancerous: FKBP6, INTS1 and ZNF516. As abnormalities progress, these genes were more likely to have a chemical methyl group attached to their DNA in certain spots. As an aside, the anti-aging medication physicians would venture that preventing methylation, and reversing methylation, would ultimately attack the problem at the root. Most physicians have been focused on disease cure rather than prevention as we have lacked effective testing to show us how to track the results of therapy.
Using methylation as a value to diagnose cervical malignancy, the three genes together showed a 90 percent sensitivity, meaning that their presence was able to predict a true positive cancer sample this percentage of the time. This new test uses those three genes and added one HPV viral gene HPV16-L1 to test for in urine The gene the virus, HPV16-L1, which also becomes methylated in human cells as cancer develops. So there it is, even the HPV virus gene ages and becomes more deadly!
The research was funded by National Cancer Institute grants (U01 CA084986, K01 CA164092 and U01 CA084986).

Tuesday, November 22, 2016

Top Form Tuesday: Vaginal Health Plan verses Vaginal Medical Therapies

Vaginal health for the average woman means: not getting infections, having comfortable  intercourse, being able to be aroused and have an orgasm; vaginal health is also, to most women, about not having bladder symptoms, not having unusual discharge, and not having unusual odor. It can be more complex than those features: vaginal health also means maintaining the pelvic floor, maintaining skin health, and maintaining a youthful look and function to the tissue. For the FDA, and many physicians, vaginal health is treating sexual pain and vaginal atrophy. While it is true that virtually 100% of women will experience vaginal atrophy and require therapy as they age, it is also true that 100% of women have concerns many years before they are atrophic and to them vaginal health needs to be approached from the wellness aspect we approach cardiovascular health, the way we approach fitness and nutrition: preventative health. While therapies  approved by the US Food and Drug Administration (FDA) abound in treatment of vaginal pain, atrophy and sexual pain due to atrophy, this approach has not begun to address what women are interested in which is staying healthy in the vaginal tissues. There is important good news for those who want to treat vaginal pain as there is a newly approved therapy that joins various estrogens and Osphena as a therapy for dysparunia. The FDA has approved prasterone (Intrarosa, Endoceutics Inc) to treat women with moderate to severe pain during sexual intercourse (dyspareunia) associated with menopause. Prasterone, a once-daily vaginal insert, is the first FDA-approved product containing the active ingredient prasterone, also known as dehydroepiandrosterone (DHEA), which is essentially a prodrug. It is thought to work by being converted to estrogen in the tissues. This step of conversion may be a better alternative or potentially an alternative to combine with other vaginal pain therapies. .
Estrogen levels decline in vaginal tissues during menopause, which may lead to vulvar and vaginal atrophy (VVA) and contribute to pain during sexual intercourse. Women with vaginal pain, especially with hormonal therapies have to continue getting pap smears, as one of the side effects of these hormonal therapies could be newly abnormal discharge or an abnormal pap. For women wanting to treat vaginal health before they get to the stage of needing medication: that begins many years before menopause, and may involve preventative care with therapies such as MonaLisa Touch or PRP therapy. Come to Discuss options at Women's Health Practice.

Friday, November 11, 2016

10 Day Fix For Your Diet

January first we often get the question of how a woman can reverse her holiday eating trend and get back to her pre-holiday weight and health. A new study has determined that ten days is a reasonable goal to improve your nutritional parameter. In a new study by Lustig RH, that looked at cutting sugar down out of one's dietary intake for the day, without changing overall calories, positive effects were seen in just 10 days. The study called: Isocaloric fructose restriction and metabolic improvement in children with obesity and metabolic syndrome published in Obesity.  in Oct 2016 underscored what why health care providers have been telling patients to simple sugars in their diet. It has been shown that even in normal weight people cutting down on sugar can reduce your chances of ever becoming diabetic. The positive health effects of reducing sugar intake can to be quite rapid in some groups of individuals. Their study of 43 Latino and African American children with metabolic syndrome, keeping total calories and calories from carbohydrate identical, a reduction from a mean of 28% of calories from added sugar to 10% significantly reduced triglycerides, LDL cholesterol, blood pressure, and fasting insulin within just 10 days. It is a good idea to get some facts: do you have prediabetes, anemia, or B12 deficiency or other nutrition issues that will take more than just improvements to treat. But , one thing we know, 10 days of lower sugar intake, without changing total calories, is a step we can all get behind.

Monday, October 31, 2016

The Exercise Prescription: It Cannot Be Given Over the Phone

Fitness is our goal, but fitness is in the eye of: well, it is a matter of discussion. For you, it may be it enough to run a marathon, for another fit enough to have a baby, and for others fit enough to be an ideal body weight. I would venture that we all want to avoid cancers and chronic diseases, and if the right exercise prescription can do that for us, then we should aim for that level of exercise. One thing is clear, it is not possible to be fit without a health evaluation. The right level of vitamins and minerals, in concert with your personal physiology and genetics, is really where you and your gyno should be aiming. The recommendation is to get above 600 MET/week, but those who have the least risk of disease are very active with over 8000 MET/week according to the research by Kyu published in the British Medical Journal. It goes without saying these are some pretty active and fit exercisers! Sleep even earns you some MET, just not very many, MET most accurately applied is measured based on your age, your health, your body mass, and the activity, it is the scientific equivalent of 'calories expended.' to know this level, you have to add up all your calculations.

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Vaginal Contraceptive Ring

If you are a female between the ages of 18 and 35 you may be eligible for a contraceptive ring investigational contraceptive medication study. Qualified participants will receive study-related medical evaluations and care at no cost. If interested, please call 217-356-3736.

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