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Friday, March 3, 2017

Your Brain is Talking To Your Fat, and The Other Way Around: The Brain-Fat Axis

We have talked, in women's health, a lot about the HPO: the endocrine system that communicates between the H: the hypothalamus, the P: the pituitary gland, and the O: the ovary. Generally speaking when we talk about 'hormone imbalance' the gynecologic endocrinologist means there is something off with this cycle of how the ovary talks to the brain. Now it has been realized that other endocrine systems have just such a channel of communication and how that works between the brain and the adipose tissue has  now been called the "brain-fat axis" and this is an important control of how your body uses energy, or decides to amass fat stores. It is now well-known that appetite-regulating peptides that were studied as neurotransmitters in the central nervous system can act both on the hypothalamus to regulate feeding behavior and also on the adipose tissue to modulate the storage of energy. Energy balance is thus partly controlled by factors that can alter both energy intake and storage/expenditure.  Exercise and  the types of food you consume in your daily diet work in mysterious ways to control what you weigh.. Ultimately this is the simplistic way we understand that bariatric surgery or extremely low calorie diets work. It is also how the medications we use for weight control work: but they work first on the forces that control both intake and the metabolism of the intake, then in turn making those food and exercise choices translate into body sculpting . A greater
understanding of the brain-fat axis and regulation of fat deposition bythe biologically active molecules produced in our body,  to help gain strategies to prevent or treat being overweight or obese..

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