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Tuesday, October 4, 2016

Gardasil Gets An UpGrade: More HPV Prevention

We may be one step closer to our dream of eliminating cervical cancer. On  the US Food and Drug Administration (FDA) in December of 2015 approved Gardasil 9, a human papillomavirus (HPV) vaccine from Merck that prevents cancers and other lesions caused by nine HPV types, five more than the original Gardasil protected against. There is virtually 100% protection of the HPV type you get in a vaccine if you have not yet been exposed to that vaccine. The first vaccine protected against
 HPV types 6, 11, 16, and 18. Gardasil 9 covers these as well as types 31, 33, 45, 52, and 58. These latter five are currently responsible for roughly one in five cases of cervical cancer. In the earlier vaccine there was some cross protection of other viruses, and since there are 14 HR types of HPV we can project some cross protection there as well. Gardasil is indicated  for girls and boys ages 9-26. Gardasil 9 is given on the same schedule. There is no indication to repeat Gardasil if you have had the earliest version of the shot. And the risks are both low, and unchanged from the first Gardasil vaccination.
As per Medscape web site Gardasil 9 is indicated in females aged nine through 26 years for the prevention of:
  • Cervical, vulvar, vaginal, and anal cancer caused by HPV types 16, 18, 31, 33, 45, 52, and 58
  • Genital warts caused by types 6 and 11
  • Various precancerous or dysplastic lesions of the cervix, vulva, vagina, and anus caused by types 6, 11, 16, 18, 31, 33, 45, 52, and 58
It is also indicated in males aged nine through 15 years for:
  • Anal cancer caused by types 16, 18, 31, 33, 45, 52, and 58
  • Genital warts caused by types 6 and 11
  • Anal intraepithelial neoplasia grades 1, 2, and 3 caused by types 6, 11, 16, 18, 31, 33, 45, 52, and 58.

More information on today's decision is available on the CDC or the  FDA's website .

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