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Tuesday, June 21, 2016

Mirena IUD and Uterine Fbroids

Uterine fibroids and what method of contraception you choose are two separate gynecologic issues, but if you have both there are many pros and cons to discover. The IUD first has to be inserted and there are some cases of  uterine fibroids take up some space in the cavity of the uterus and it's possilbe that the IUD would be expelled after insertion. Typically we say that only about 2% of all IUDs are expelled in the first year after insertion. With uterine fibroids that expulsion rate could climb to over 10%. Your Mirena IUD can shrink your fibroids.It is known that the IUD can shrink the overall size of your uterus. Women who suffer from uterine fibroids need to get to their gyno and evaluate their reproductive plan. In a September 2010 issue of  Contraception it was reported from Jiangsu, China that they have discovered that the progestin component, the levonorgestrel, may actually both suppress the growth and cause death of uterine fibroid cells! WoW! It is important to control the growth of this common uterine tumor as they can grow quite large and produce symptoms of pain as well as symptoms of heavy bleeding. These researchers have been studying the fine points of fibroid growth. We know that it's probably a chromosome glitch in a single uterine muscle cell that gets that fibroid cell's growth unleashed and causes a tumor to grow. So they did a study of cells in culture from twenty women with fibroids who had hysterectomy. They point out that the growth, based on active DNA (ok, for the accurate scientists, actual mRNA phase of growth) was more active in the progesterone (luteal, second half) of the menstrual cycle, but paradoxically the growth of fibroids is somewhat restricted during phases of pregnancy when progesterone is very high. So they tested the levonorgesterel progesterone that is in Mirena IUD (for discussion group pop on here). There theory was that the 20 mcg/ml that is leaked each day from the Mirena (LGN-IUS to the fancy people and for info outside the USA go to the other Mirena) is about 1000 times what a normal circulating progesterone level would be, and that in their cultures after only 72 hours the growth of those cells was decreased by 24%. Wow! And furthermore, in order for a fibroid not to grow, that progenitor abnormal cell must die! And apparently that is what our hormones regulate as well. And in this research trial the physicians were able to use large doses of the levonorgesterel to induce the death of these fibroid (leiomyoma) cells. So there is a whole bunch of complex growth regulating factors, including the newest growth regulator on the block: "survivin" (I love that name, almost want to buy a cat just to use it!) and how they interact with the exact gene make up of the cells of one's uterus that ultimately determines the survive or die of a fibroid cell. And survival instincts must be pretty good since the newest estimates are that up to 50% of all women will have uterine fibroids before they die! The best news yet is that these researchers aren't done, they have all sorts of new proposals to look at how this might work. And if the use of the progesterone containing IUD doesn't suffice to shrink your fibroids successfully, it may be time to try other therapies. Call 217-356-3736 if you live within range of central Illinois and wish to have this therapy, wish to participate in a research study, or if you are done with having children, you may be interested in office same day NovaSure endometrial ablation therapy.

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Thank you for your comments and questions. This blog is not intended to replace medical care, but is informational only. We hope you will become a follower or visit Womens Health Practice. We offer a variety of unique services including MonaLisa Touch, Coolsculpting, Labiaplasty, and Gynecoloigic Clinical Research Trials. For more information on menopause see http://www.amazon.com/Menopause-Make-Peace-Change

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Vaginal Contraceptive Ring

If you are a female between the ages of 18 and 35 you may be eligible for a contraceptive ring investigational contraceptive medication study. Qualified participants will receive study-related medical evaluations and care at no cost. If interested, please call 217-356-3736.

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