Cholesterol Medication Has Paradoxical Effect On Uterine Fibroids: It May Be Shrinking Them

Uterine fibroids are non-cancerous muscle growths of the uterine wall. They can be very small or grow large and only need therapy if they are causing symptoms such as pain or bleeding. No one is certain what causes the presence or growth of fibroids, but we think that they are linked to longer female  hormone exposure (early menarche, late menopause, and high estrogen states such as not ovulating regularly) is a known risk factor, as are race and hereditary. In one of the newest studies of fibroids Dr. Borahay at the University of Texas Medical Branch in Galveston investigated the effects of statin medications on uterine fibroids. 3-hydroxy-3-methylglutaryl-coenzyme (HMG-CoA) reductase inhibitors, also known as statins, are the most effective class of drugs for lowering serum low-density lipoprotein cholesterol and thus preventing;postID=2882842847954895309;onPublishedMenu=allposts;onClosedMenu=allposts;postNum=0;src=link cardiovascular disease. In this study almost 50,000 women with fibroids were compared to almost 150,000 women who did not have them. They then looked at statin medication use over the past two years and found that statins were actually somewhat protective with regards to uterine fibroids. Simvastatin was the most common statin used. In the women who used statins, but had uterine fibroids, they had less bleeding, less pain, fewer myomectomies, and actually less anemia that non-users of statins. Interestingly the rates of hysterectomy were about the same whether the patient used statins or not, in which case we may be seeing such a mild effect it wasn't enough to prevent the cases requiring major surgery. It's unclear what the reasons for the effects of these medications, it's possible there is a direct effect, it is possible it is a secondary effect of improving pelvic circulation. And if you are on the fence about using statin medication, perhaps you should weigh in any fibroids you may have been diagnosed with.


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