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Tuesday, June 3, 2014

PCOS and Pregnancy Complications Beyond Infertility

PCOS has been known for many decades to be a prominent cause of infertility, but now in a new study from Italy and the Instituto di Ricovero e Cura a Carattere Scientifico PCOS has been linked to causing pregnancy problems. In their study they showed that the PCOS women had more miscarriages, more diabetes, more hypertension, more preeclampsia, and other problems of pregnancy. They studied a group of women who were PCOS but essentially normal weight and no other confounding problems such as smoking. And they were surprised to find that low-grade chronic inflammation in their system was made even worse during the pregnancies of women without polycystic ovarian syndrome (PCOS)  according to a study published online May 29 in the Journal of Clinical Endocrinology & Metabolism. WBC counts, ferritin levels, and CRP were used to track inflammation during pregnancy. These markers, along with other markers of inflammation have already been implicated as causes of cardiovascular disease. Theoretically this could thus also have an impact on the placenta which is a factor in all of these problems of pregnancy. As with all small studies, experts have not rushed to assert ways to prevent the complications. In cardiovascular disease we use exercise, weight loss, nutrition, and even medical treatments such as statins,
and low dose aspirin to treat elevated inflammation. In pregnancy planning, do not skip evaluation of your cardiovascular system, it's important for overall health even if it doesn't turn out to reverse the complication rates seen with PCOS moms. At Women's Health Practice, we offer a variety of ways to test your body's inflammation.

Reference from Medscape: J Clin Endocrinol Metabol. Published online May 29, 2014. Abstract

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