Ovarian Function and BRCA Genes

The average age of menopause is around 50, 51.4 in many studies, as early as 49 in others. Factors have been discussed in other posts as to conditions that cause premature menopause, or menopause prior to the age of 40. Ovarian aging has also been discussed in posts regarding fertility as a women ages from her 20s to 30s to 40s. Now we have discovered a new factor that leads to earlier menopause which is being BRCA1 and BRCA2 carrier. The earlier age of menopause in BRCA mutation carriers probably have to do with the aging of their DNA within the ovary which can no longer regenerate any eggs. Because of this they are more prone to infertility and miscarriage as well. Many women who carry these genes are not yet aware they have them and it is worth talking to your gyno about whether you should be screened.


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