Teen PCOS Can Lead To Liver Disease That May Persist Into Adult Years.

Polycystic ovarian syndrome (PCOS) occurs in about 10% of the female population. It's onset is typically in one's youth, although many will not manifest significant symptoms until they get in their 20s. Typically gynecologists have been focused on cyst formation and pain, the presence of infertility, or the presence of male hormone related side effects such as acne or abnormal hair growth patterns. As we have begun to understand more on the disease of PCOS we realized that it can be a significant factor in obesity, and obesity can worsen the condition. Now the link between abnormal metabolism and PCOS has begun to be revealed as more than just a significant problem of midline weight retention. Researchers in the Division of Weight Management, Children's Hospital of Pittsburgh, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, and as reported in Fertility and Sterility  have discovered that teenagers with polycystic ovarian syndrome (PCOS) can develop fatty liver disease if they also have insulin resistance, a form of pre-diabetes or diabetes. The teens studied were also obese, and most all had abnormal blood fats including high cholesterol.
To investigate the relationship between liver fat and in vivo insulin sensitivity, body composition, abdominal adiposity, and lipid metabolism in obese adolescent girls with polycystic ovary syndrome (PCOS). Liver fat deposits if allowed to go unchecked can lead to liver failure and difficulty processing medications and even difficulty with food, and also lead to more abnormal hormone levels and abnormal blood fat levels. Liver fat is directly associated with increasing age, even in the narrow adolescent age range, and the older one is the worse liver fat is. We find that girls and young women with PCOS have increasing abdominal adiposity, worsening insulin sensitivity, and dyslipoproteinemia and the more obese they are, the worse these conditions become. Targeting these abnormalities early in the course of PCOS may halt future nonalcoholic fatty liver disease in adulthood.The liver is the source for much of the detoxification of foods and medicines and it is important to maintain liver health as we age.

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