What I want To Know About This Cave Woman

The news broke that a 10,000 "anscestor's" (she probably wasn't from the tribe we were as her branch died off) DNA had been sequenced. My immediate first reaction was wow, how Jurassic park of them. But not dwelling on the childhood obscession with dragons for long, I began to mete out the real questions I have for those scientists! How were their tumor suppressor genes. In general we have to fight cancer on a cellular level everyday. The tumor fighting genes essentially will either check cell growth or cause the cell to age quickly or cause outright cell death. These are very powerful functions, and our body has long designed a very complex way of keeping these actions in check, as we don't want these biologic functions getting too out of hand. You probably have heard a lot about the genes that get out of control and cause breast cancers, but some of the other ones just don't have the press core excited about them yet. There is TP53 that is bent and broken in many ovarian cancers, there is the PTEN that has to do with the N-terminal Peckstrin homology domain that gynos can't understand but is the most commonly disturbed gene that causes endometrial (uterine) cancer, and then the gene that I have been following called the FHIT gene. This gene is actually named the fragile histidine triad and it's on your third chromosome. And it's fascinating to gynos because it is where HPV most frequently attacks. In fact almost half of all precancers of the cervix in one study were found to have a broken FHIT gene. The obvious question, is do you have this and can we fix it! But maybe before we get down to that question, lets ask these German researchers if their ancient devotchoka how was her FHIT gene? Were the Denisovans as susceptible to HPV as we are?


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