Estrogen Receptor Lack Can Lead to Testosterone Ineffectiveness

Generally when we prescribe a hormone we expect that we will get the effects of that hormone. But most women forget to think about how individual hormones are metabolized. It how they are metabolized that will most often determine how they function. Testosterone in women is metabolized to estrogen, and much of it's hormone effect is through the receptors of estrogen action. If a menopausal woman doesn't have estrogen receptors then she is not likely to have as much effectiveness from her testosterone use as a woman who has these cell receptors. The way we get estrogen receptors is usually with the use of estrogen. So this may be why women using testosterone in menopause are not as successful with their therapy as women who use both estrogen and testosterone.

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