BRCA 1/2 Negative But May Still Be Genetically At Risk For Ovarian Cancer

Gynos are still struggling to detect early stage ovarian cancer. The best we've come up with so far is to eliminate risk in those that genetically are at the highest risk. Women with BRCA 1 have about a 50% risk by age 50 and those with BRCA 2 have about an 85% lifetime risk of ovarian cancer. Ovarian removal in these women can reduce these risks down to extremely low rates. We now think that there is another genetic variant that helps explain the families of women who have risk but test negative for BRCA 1 and 2. This is the new test called PrOvar. It's very new, it's not widely available, and it's in the development phase.Remember, that pelvic examinations, close attention to how you feel, and in some cases pelvic ultrasounds, and when indicated, 3-D imaging will help identify women who already have disease. Once you have disease, Ova1 testing may be indicated to get proper treatment.


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