Bioidential Hormones or Synthetic Hormone Use In Menopause Healthier For Your Breast?

Breast tissue responds to many hormones. Gynos focus mostly on the potential ability of estrogen and progesterone to affect the rate of breast cancer in women as they age. One question that still remains is it better to use a natural bioidentical hormone or synthetic version, in terms of any breast cancer risk.  A group of researchers supported by the Swedish Cancer Society and reported in the March 2011 issue of Fertility and Sterility compared giving natural estrogen gel daily and oral natural progesterone to the conjugated estrogen and synthetic medroxyprogesterone to 77 women over two months. They took actual before and after breast biopsies to see if one therapy had more short term effect on the breast tissue growth than the other therapy. Their conclusions did not achieve what scientists call statistical significance. In other words, their results could very well have been just due to chance, or the fact that it was a very short term study, and unfortunately they weren't able, with their technique of core biopsies to always get enough tissue from every case, so they really only had usable material from 49% of the patients.. The synthetic hormone group had more proliferation (growth) than the other group, but again, just barely as per the scientific evidence. They also looked at a complicated biological process called apoptosis, by which the body gets rid of cells in the natural process of keeping healthy cells and turning over cells. And the bioidentical hormones actually seemed to facilitate apoptosis (cell death to eliminate abnormal tissue) more. So this was another sign, but not proof, that the natural hormones, for some women, may have some benefit.So when women look into hormone therapy in menopause, this is one more piece of advice they may want to heed.


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