Hormones and Pains in the Leg AND Deep Vein Clots

Pains in your legs may mean that you have deep vein clots. There are physician performed tests, office tests and radiologic studies that can determine whether you have one of these clots. For women who have suffered a clot it's important to understand if you have a medical or genetic condition that could have led to these clots. Many blood factors lead to proper blood clotting, which we need to heal from cuts. But imbalances in some of these factors can predispose us to clot risk. Some factors cause clots: so you don't want to much of them, others prevent clots, you need enough of these factors. Protein C and Protein S are vitamin K dependent regulatory factors that can, if deficient, predispose us to clots. But a woman may be deficient because genetically she cannot produce the right amount or type of these factors.  In fact a woman who is Protein S deficient has about a 50% risk of developing a clot before age 50, but unfortunately, most women with these conditions don't get diagnosed until after the clot! Understanding the molecule of activated protein C is important, and how our hormones . Estrogen can induce activated protein C resistance. Perhaps progesterone can too. Thus testing when on pills, or hormone replacement therapy or pregnant can give face readings. But when a woman has leg pains, especially if there is a confirmed or suspicion of a blood clot,  she needs to be evaluated for problems with these blood factors


  1. Deep vein clots in the thigh are more likely to travel to the lungs than are those of the lower leg.


  2. The reader wrote that deep vein clots in the thigh are more likely, than those in the lower leg, to cause the serious condition of a clot in the lung. An important fact for patients and their providers to consider is that "a clot in the lungs" known as a Pulmonary embolism, can present with a variety of symptoms. The initial symptoms may be from a clot that could originate in the leg, therefore be leg symptoms; or the initial symptoms can be respiratory symptoms such as being very short of breath with sitting or with any exertion. So only testing can confirm that there is or isn't a clot in the lung.


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