CSI Team of Endometriosis!

The microscopes were focused and theories were being parleyed, and guesses from the audience were getting closer and closer: it was a scene from CSI? No! It was gyno gab, wondering about pelvic symptoms and finding endometriosis: where did this endo come from? Ghost whispering could have been heard if they were quiet enough. It could have been the ghost of the original CSI investigator of endoemetriosis: Dr. John Sampson had been there before. After careful study of what t was once thought to be 'odd odd pelvic implant,'s in 1921 he coined the term endometriosis. He had his theory, and he was thought to be correct as this is still the one we give to patients daily as an explanation for their case of endometriosis. Dr. Sampson proposed that the blood with fragments of lining tissue of the uterus from menstrual periods would bleed down the fallopian tubes and implant in the pelvis to cause this disease. Others followed with their own CSI experiments of endometriosi showing that this blood was indeed 'live' and capable of implanting in the pelvis and this was tested in animal models most famously orangutangs studied in animal laboratories. But in a far away lab in Mumbai, India, the theories have begun to meld into proof. Where does endometriosis come from? The pelvis or grow spontaneously? The answer is definitely progress towards a cure! As reported in the November 2010 journal of Fertility and Sterility the biotech department researchers headed by Nina Chelma-Patel probed into this deeply. The protein patterns, CAD images, genetic characteristics, gel electrophoresis of endometriosis tissues were studied, and compared with normal tissues evaluated with sophisticated statistical analysis were all utilized for the first time. The finding showed that by their studies using a sophisticated test called Western Blotting techniques the patterns seen were very different between a woman's natural healthy  lining tissues to the uterus called the endometrium and the similar, but tissue from the abdomen called endometriosis tissue with at least 11 novel proteins that showed up in the cases of endometriosis. What we want to go back and ask Dr. John Sampson over a mythical dinner is, if lots of women have open fallopian tubes and getting menstrual blood in the pelvis is common, why is it we only diagnose endometriosis in a group of women and not the majority? Is this retrograde theory sound do these tissues really begin in the woman's uterus or do they grow spontaneously in the abdomen? GynoGab would  chime in that women with larger uteri with heavier periods (fibroid uterus being the best example) are more likely to have endometriosis in some studies. So the clinical CSI team has bought this theory all along. What do the Mumbai researchers say? Their verdict: is the tissue is different. And what does the Gyno Gab Gal say: how that difference is manifested, is ultimately the actual answer to origin, and what we hope will also be a cure! You have new evidence for this unsolved CSI case? Bring it on. 


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