What Would Guyton and Hall Say About This New Vitamin D Proclamation?

The morning news was buzzing with a cure for Diabetes in Pregnancy, Infections in Pregnancy, and Preterm Laber (well, not a cure, but half the rate of complications). Women took 4,000 IU of the vitamin daily in their second and third trimesters showed no evidence of harm, but they had half the rate of pregnancy-related complications as women who took 400 IU of vitamin D every day, says neonatologist and study co-researcher Carol L. Wagner, MD, of the Medical University of South Carolina. It's normal recommendations of Vitamin D levels have hovered between 200 and 400 IU for many years.Dr. Ruth Lawrence of the Dept of Peds fro the University of Rochester, and popular Breastfeeding guru, mentioned it could possibly be a cure for Toxemia. I'm raising my eyebrow now as I do hail from the state that brought us thenow infamous publication from researchers Dr.Silvio Aladjem and Dr. Judith Lueck who proclaimed in 1983 that the syndrome of Toxemia in pregnancy was associated with a microscopic hookworm type organizm they discovered and  named Hydatoxi lualba. It turned out that it's a very good thing to keep one's microscope very clean, and back up your research with a lot of facts.But they did get published, and very famous, but I digress. So here we are back to massive Vitamin D doses in pregnancy, a treatment we have previously told patients could cause birth defects.  And further curious thing I noted from Gyton and Hall, the commonly used medical school physiology text, in there it says that above a certain level of intake, (moms) we will have a steady blood level of Vitamin D3 (or 25-hydrocholecalciferol) which is the active form of Vitamin D. In fact they seem to indicate that even at levels of intake of 2.5 times normal blood levels maintain steady. Maybe a graph that needs tweaking a bit, my version of the text is 2006, and Arthur Guyton was already deceased, but if anyone gets a chance to run into Professor John Hall at Univ Mississippi Med Center in Jackson can you ask him what he thinks. Although this study said that if moms took the "10 times more" they were" less likely" to have low levels, I'm wondering...what really was their intake, and what level do we really need to go to, and what mechanism of action is this acting. Is there some local placental or fetal level.


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