Endometriosis Physiology: Cells That Die

No one really knows the cause of endometriosis other than the primitive, but still thought valid theory of Sampson and retrograde menstrual bleeding; but we are getting more and more clues. New research says that we can attribute female pelvic endometriosis on the genetic component the Bcl-2 regulator of cell death. Some cells in our body must die. This is a good thing. As women we know this well, after all what is our monthly cycle about if not cells dying and regenerating. Our uterine lining has die off, slough off, out of our uterus, and renew itself in preparation for a potential birthing ground in the next cycle. How does that uterus with healthy lining tissue exactly know that we are not really pregnant and that it's safe for the blood vessels to wither, the tissue to shrivel, and get new cells to burst and release from the frazzled lining? The answer is in this compound Bcl-2, as long as it's around well the lining tissue, known as the endometrium, will not die, but live, and if not, it's a signal to halt this cycle and go on to the net.. Well, there are other factors, tons of them, but the Bcl-2 is an important one. So if you have a local deficiency of the Bcl-2, the tissue lives on, and on, and on. So does this sound familiar, yes! Endometrial lining tissue, that both refuses to just confine itself to the uterus and that refuses to behave like lining tissue that is sloughed and dies off monthly, but instead lives in places like the ovary or pelvis is endometriosis. So finally here is some real scientific proof on the inciting factor that leads to endometriosis in women! This endometriosis research work is being done at Ajou University in South Korea, by a group of scientists studying the triggers for this deficient Bcl-2 activity. This deficient Bcl-2 production can be found on our chromosome number18. Now knowing about a gene, and fixing it may be two different issues. For most gynos, we can't make use of the science behind the condition, it's the physical symptoms our patients report, like painful periods, that bring to our attention the disease!


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