Should you get a B6 tst or a PLP test?

For some reason we focus on what goes into our mouth, not what is active in the body. We talk about this with vitamin D. D3 (calciferol) is actually the active metabolite of D. And now, here's another fact: B6's active form is Pyridoxil 5-phoshate or (PLP). Nutritionists have called it pyridoxine.  And PLP (think B vitamin) is necessary for about 100 important nutritional enzamatic reactions, and about another 40 or so are mentioned by the molecular biologists that name these things. And an interesting study coming from the Karolinska Insitute and published in JAMA in March 2010 has looked at both the level of B6 in diet and PLP in blood, and confirmed the statistical trend that your chance of colorectal cancer gets less and less the better your PLP levels are. Now we have to consider that this may be just one of those statistical things. The best evidence is always from a study that proves the link between a health behavior and an outcome. There is a bit of that in a folate (no, that's a different B, B9 to be exact) and asprin supplementation to reduce the polyps that are pre-cancerous, they did show that B6 was important for prevention. So lets believe this evidence for now. And for women over the age of 50 (none of us are talking about anyone specific) the Swedish researchers found that as man as 2/5 women may have substandard levels of PLP from food. So name some favorite PLP enhancing meals: I think I'll have a beef fajita with lots of avocado, and then I'll work off the extra fat with a couple more laps in the pool, tomorrow.


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