Making Endo Not Hurt

Endometriosis causes pain. We need to cure patient's pain if we are to have successful treatment of the condition. A riddle wrapped in a puzzle surrounded by an enigma, or something along those lines is pretty much how we still face endometriosis. We know it when we see it, it's extraordinarily common, and well, there's not really been a new treatment for it in the past 20 years which was the date that Lupron Depot got approval for the treatment endometriosis. DMPA 104 mg did get approval in 2005, but that was just really tagging an approved indication to something physicians were using anyway. Some women struggle with infertility, but the most devastating part of the condition is the pain women suffer when they have endo. Shrinking the implants with direct effect, reducing overall inflammation, and directly suppressing the plasminogen activator in implants (pay attention to this term, it's hot in the heavy menstrual bleeding sector) so they won't bleed is how birth control pills, specifically the progesterone component works. Researchers from Australia have another approach, they are hitting endometriosis pain where it counts. Kind of like Willie Sutton's approach to bank robbery that's where the money is...Dr Toukige and his crew at the QE II Research Institute from Mothers and Infants at the University of Sidney thought where is pain generated: nerve fibers! And sure enough, they've been able to study the distinctive effects of progesterone on the collection of nerves and their behavior in patients being treated for endometriosis. The effects on various types of endometriosis lesions seems to vary, in part because progesterone may not be the most potent suppressor of estrogen produced locally in the tissue with endometriosis. But it makes a lot of sense, and finally there is progress in the understanding of the pain of endometriosis that may someday enable us to make all women with endo pain free.


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