Anti-Estrogen to Produce Estrogen: The 'Newest' Way to Get Pregnant

It may not actually be the newest way to make your ovary make estrogen then produce a fertile egg from the sleeping follicle, but using an anti-estrogen is still one powerful way of achieving this end. The newest issue of Fertility and Sterility (Sept 2009) delves into the mystery of why the anti-estrogenic fertility treatments clomiphene citrate and letrozole work to improve ovulation. Clomiphene has been used since the 1970s so it's safety and track record are well known. But in using anti-estrogens the down side can be a dry cervix with poor mucus, a thin uninhabitable by a nascent placenta-to be uterine lining, or plain resistance in up to a fifth of the patients. So the use of competitor medications, especially for PCOS patients, has become increasingly popular. The use of the letrozole medication may be hampered by the fact that when used alone the ideal dose has not been determined. Another less known fact to consider when picking a medication to use for ovulation, Clomid has a very long half life: up to two weeks for full clearance out of the blood stream, this leads to long estrogen receptor (ER) depletion so it is a bit more likely to produce extra eggs: good for those wanting twins, not so much for those hoping to avoid! If this is slowing your Baby Mama plans down, come in to talk to your Gyno Gab Gal today!


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